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It is used to treat adults with type 2 diabetes (high blood sugar levels due to insulin resistance) as an adjunct to diet and exercise to help improve blood sugar control.
Pioglitazone Hydrochloride 30 mg Tablets
What is pioglitazone hydrochloride and what is it used for?
Pioglitazone hydrochloride belongs to a class of medications known as thiazolidinediones.
Do not take pioglitazone hydrochloride:
If you are allergic to pioglitazone hydrochloride or any of the ingredients in this medicine. Tell your doctor about the allergy and any signs you experience.
If you have been diagnosed with NYHA Class III or IV heart failure (an advanced stage of heart failure, a disorder that causes the heart muscle to lose its ability to pump blood properly).
Warnings and Precautions:
Talk to your doctor or pharmacist if you experience allergic reactions such as shortness of breath, rash, swelling of the face or neck, low blood pressure, or dizziness. This medication may cause fluid retention, which can worsen or lead to heart failure.The risk of fluid retention has been shown to be higher in patients using insulin with this medication who have NYHA Class I and II congestive heart failure (the first classes of heart failure; NYHA Class I means you have no symptoms and no limitations on normal physical activity, such as shortness of breath when climbing stairs or walking; Class II means you have mild symptoms, such as mild chest pain or shortness of breath and mild limitations during normal physical activity).Be sure to talk to your doctor before starting this medication if you have heart problems (such as heart failure).Talk to your doctor if you experience signs of heart failure while taking this medication, such as swelling of the feet, ankles, or abdomen, weight gain, fatigue with exertion, difficulty breathing, or irregular heartbeat.This medication may cause edema (swelling), which is dose-related. If this occurs, be sure to tell your doctor. Your doctor may reduce your dose if necessary.This medication may be associated with liver problems, which can be fatal. If your doctor suspects liver damage, they will ensure you stop the medication immediately and evaluate you for the exact cause of the liver damage.This medication should not be restarted if your doctor cannot identify another possible cause of your liver damage.Your doctor may recommend liver blood tests if you have liver problems and will decide accordingly if any dose adjustments are needed.This medication may increase the risk of fractures in female patients.This medication may increase the risk of bladder cancer, especially when used for a long period of time.Be sure to tell your doctor if you have bladder cancer or if you have previously had bladder cancer. You should not take this medication if you have bladder cancer.This medication may cause hypoglycemia (low blood glucose levels) when given with insulin or an insulin secretagogue.Your doctor may recommend a lower dose of insulin or an insulin secretagogue to prevent hypoglycemia.Talk to your doctor if you experience signs of hypoglycemia, such as shakiness, tremors, palpitations, sweating, and dizziness.High blood glucose levels may lead to macular edema (eye edema). Regular eye exams at your doctor's office are recommended.
This medication has not been shown to reduce the risk of major vascular outcomes (such as heart, kidney, eye, brain, and nerve complications).
Talk to your doctor before taking this medication if you have liver problems, heart failure, type 1 diabetes (juvenile diabetes), or diabetic ketoacidosis.
Your doctor should perform certain blood tests, including HbA1c (used to assess blood sugar control), before you start taking pioglitazone.
Talk to your doctor before taking this medication if you are a premenopausal woman (a woman of childbearing potential). This medication may increase ovulation, which may increase the chance of pregnancy.
Ask your doctor about birth control methods you can use to prevent pregnancy while taking this medication. Be sure to tell your doctor immediately if you become pregnant while taking this medication.
Possible Side Effects:
Possible side effects include signs of an allergic reaction, such as skin rash and itching; signs of heart failure, such as swelling of the feet, ankles, or abdomen; weight gain; fatigue with exertion; difficulty breathing; and irregular heartbeat; signs of liver problems, such as stomach pain, nausea or vomiting; unusual or unexplained tiredness; urination; yellowing of the skin or whites of the eyes; loss of appetite; edema and weight gain; fractures; bladder cancer; hypoglycemia (when taking insulin or other diabetes medications); and signs of macular edema, such as vision changes. Other possible side effects include upper respiratory tract infections, sinusitis, headache, muscle pain, sore throat, laboratory abnormalities, ovulation problems, and an increased risk of pregnancy.
Other Medications and Pioglitazone Hydrochloride:
Tell your doctor or pharmacist if you are taking, have recently taken, or might take any other medicines, including prescription and nonprescription medicines, herbal products, vitamins, and supplements.
If you are taking gemfibrozil (used to treat high triglycerides).
If you are taking rifampin (an antibiotic).
How to take pioglitazone hydrochloride:
Adults
The recommended starting dose is 15 mg or 30 mg orally once daily.The starting dose should not exceed 15 mg once daily in patients with NYHA Class I or II heart failure.Your doctor may increase the dose in 15 mg increments if your heart failure is not controlled.
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