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Celecoxib is used in adults to relieve the signs and symptoms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
• Celecoxib belongs to a group of medications called nonsteroidal anti-inflammatory drugs (NSAIDs).
Celecoxib 200 mg Capsules
What is celecoxib and what is it used for?
• Celecoxib is used in adults to relieve the signs and symptoms of rheumatoid arthritis, osteoarthritis, and ankylosing spondylitis.
• You should expect your medication to start working within hours of taking the first dose, but you may not feel the full effect for several days.
What you need to know before you take celecoxib:
Do not use celecoxib if:
• You are allergic to celecoxib or any of the other ingredients in this medicine.
• You have had an allergic reaction to a group of medicines called "sulfonamides" (for example, some antibiotics used to treat infections).
• You currently have a stomach or intestinal ulcer or bleeding.
• You have had asthma, nasal polyps, severe nasal congestion, or an allergic reaction such as a rash, itching, or facial swelling after taking acetylsalicylic acid or any other nonsteroidal anti-inflammatory drug (NSAID). Swollen lips, tongue, or throat, difficulty breathing, or wheezing.
• You have severe liver disease.
• You have severe kidney disease.
• You have an inflammatory bowel disease, such as ulcerative colitis or Crohn's disease.
• You have heart failure, confirmed ischemic heart disease, or cerebrovascular disease, for example. You have been diagnosed with a heart attack, stroke, transient ischemic attack (a temporary reduction in blood flow to the brain; also known as a "mini-stroke"), angina, or a blocked blood vessel in the heart or brain.
• You have or have had circulation problems (peripheral arterial disease) or have had surgery on the arteries in your legs.
Warnings and Precautions:
Talk to your doctor or pharmacist before taking celecoxib:
• You have ever had an ulcer or bleeding in your stomach or intestines.
• You are taking Celebrex at the same time as other NSAIDs that do not contain acetylsalicylic acid, such as ibuprofen or diclofenac. These medications should be avoided together.
• If you are a smoker or have diabetes, high blood pressure, or high cholesterol.
• If your heart, liver, or kidneys are not working well, your doctor may want to monitor your condition regularly.
• If you experience fluid retention (such as swelling of the ankles and feet).
• If you are dehydrated, for example, due to illness, diarrhea, or the use of diuretics (used to treat excess fluid in the body).
• If you feel ill due to an infection or think you may have an infection. If you are over 65 years of age, your doctor will want to monitor you regularly.
• Consuming alcohol and NSAIDs may increase the risk of gastrointestinal problems.
Other medications and celecoxib
Celecoxib may interact with:
• Dextromethorphan (used to treat coughs)
• Steroids (cortisone)
• ACE inhibitors Angiotensin II antagonists, beta-blockers, and diuretics (used for high blood pressure and heart failure)
• Fluconazole and rifampicin (used to treat fungal and bacterial infections)
• Warfarin or other warfarin-like drugs (blood thinning agents that reduce blood clotting), including newer drugs such as apixaban
• Lithium (used to treat some types of depression)
• Other medications to treat depression, sleep disorders, high blood pressure, or irregular heartbeat
• Antipsychotics (used to treat certain psychiatric disorders)
• Methotrexate (used to treat rheumatoid arthritis, psoriasis, and leukemia)
• Carbamazepine (used to treat epilepsy/seizures and some forms of pain or depression)
• Barbiturates (used to treat epilepsy/seizures and some sleep disorders)
• Cyclosporine and tacrolimus (used to suppress the immune system, for example, after a transplant)
• Celecoxib can be taken with a low dose of acetylsalicylic acid (75 mg or less daily). Ask your doctor for advice before taking both medications together.
How to take celecoxib:
Celecoxib is for oral use. The capsules can be taken at any time of day with or without food. However, try to take each dose of Celebrex at the same time each day.
Contact your doctor within two weeks of starting treatment if you do not experience any benefit.
The recommended dose is:
One capsule daily. Your doctor may increase this to a maximum of two capsules if necessary.
• Make sure your doctor knows if you have liver or kidney problems, as you may need a lower dose.
Celecoxib is for adults only, not for children.
Possible side effects:
Stop using the product and seek immediate medical attention if you experience hives, rash, chest tightness, wheezing, chest pain, severe stomach pain, or jaundice.
How to store celecoxib:
• Keep this medicine out of the sight and reach of children.
• Do not use this medicine after the expiry date printed on the blister and carton. The expiry date refers to the last day of that month.
• Do not store celecoxib above 30°C.
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